The widespread use of single-use plastic eye drop bottles in ophthalmology presents a significant environmental challenge. While essential for preventing contamination and ensuring patient safety, these bottles contribute to plastic waste due to their small size, multimaterial composition, and inadequate recycling infrastructure. This review examines the environmental impact of eye drop packaging across various ophthalmic conditions, including dry eye disease, cataract surgery, and glaucoma, highlighting the substantial cumulative burden of plastic waste and carbon emissions. The manuscript explores innovative solutions to mitigate this environmental footprint without compromising clinical standards. Key strategies discussed include product redesign using biodegradable materials, the adoption of multidose preservative-free systems, and the development of alternative drug delivery technologies like punctal plugs. Additionally, the importance of advanced recycling initiatives, such as specialized take-back programs, is emphasized. The paper also underscores the need for behavioral, institutional, and policy interventions, including educational campaigns, sustainable procurement practices, and the implementation of Extended Producer Responsibility (EPR) policies. By integrating these multifaceted approaches, the field of ophthalmology can align the critical priorities of patient safety and environmental sustainability, fostering a transition towards greener practices while maintaining high standards of care.