This publication addresses the intersection of two pressing challenges in Latin America: food waste and plastic packaging. In Brazil, Colombia, and Mexico, supermarkets and retail chains are expanding rapidly, reshaping how food is packaged, sold, and discarded. Packaging reduces spoilage and supports food safety, yet it also creates large volumes of plastic waste that existing collection and recycling systems cannot manage. The central question guiding this report is: how can packaging be rethought so that it prevents food loss without generating new environmental burdens? To answer this question, the report is organised in three interconnected parts: Part I builds the analytical foundation by examining how packaging practices, food loss dynamics, and retail systems interact, particularly across Brazil, Colombia, and Mexico. Part II explores practical and scalable solutions that can reduce both food and packaging waste. Part III looks ahead, outlining the policy frameworks, behavioural enablers, and strategic recommendations needed to scale these solutions and guide the region’s transition toward circular, low-waste food systems.