Reverse logistics (RL) and the closed-loop supply chain (CLSC) are integral parts of the holistic waste management process. One of the important end-of-life (EOL) products considered in the RL/CLSC is Waste Electrical and Electronic Equipment (WEEE)/E-waste. Numerous research papers were published in the RL and CLSC disciplines focusing WEEE separately. However, there is no single review article found on the product-specific issues. To bridge this gap, a total of 157 papers published between 1999 and May 2017 were selected, categorized, analyzed using content analysis method. The method involves four steps: material collection, descriptive analysis, category selection and material evaluation. For the systematic literature review, the steps were followed and four main types of research in the field of RL and CLSC of E-waste, namely designing and planning of reverse distribution, decision making and performance evaluation, conceptual framework, and qualitative studies were identified and reviewed. Research gaps in literature were diagnosed to suggest future research opportunities. The review first of its kind that may provide a useful reference for academicians, researchers and industry practitioners for a better understanding of WEEE focused RL/CLSC activities and research.