Recognizing the rapidly emerging and serious issue of Waste Electrical and Electronic Equipment (WEEE) or E-waste management, this manual on WEEE/ E-waste has been prepared as a guidance document to support development and implementation of WEEE/Ewaste management system. This manual has been prepared based on data from secondary sources including publications from scientific journals, reports and web sites. The challenges of the WEEE/E-waste management that the countries are facing involve the design of WEEE/E-waste take-back system along with the financial mechanisms to sustain it. Countries that already have WEEE/E-waste regulations often encounter difficulties when putting the regulations in practice. The difficulties are derived from lack of mechanisms in the flow of WEEE/E-waste in the WEEE/E-waste life cycle. They feel the need to plan and adopt the most effective collection and transport systems to accompany the regulatory systems. This manual covers essential components to plan, design and implement a take-back system at local and national level. For the take-back system, the efficient collection and transport of WEEE/E-waste can be achieved by surveying the waste trade and material flow and identifying necessary mechanism to minimize handling, to use adequate means, etc. The fundamental principle for development of E-waste policies/laws/regulations is based on the conceptual life cycle of WEEE/E-waste. Regulatory systems and identification of stakeholders and their responsibilities are important as they provide foundation and underpin the take-back schemes. The financial viability of all the stage of WEEE/E-waste management chain is vital for its implementation. Therefore, the allocation of economic responsibilities should be defined and should find its application that best matches the country’s conditions. Examples can be drawn from current models for financing E-waste tack-back activities in use. Finally, case studies and information is provided on different approaches and regulations that will enhance the practitioner's knowledge in WEEE/E-waste management, especially the take-back mechanism in both developed and developing country contexts.