The improper storage and disposal of unwanted or unused household pharmaceuticals in the State of Wisconsin poses many health, safety and environmental risks—including drug abuse, accidental poisoning and water pollution. While household take-back programs aim to reduce these risks by providing healthier, safer alternatives to landfill and sewer disposal methods, the Wisconsin Department of Natural Resources (DNR) has determined that additional data are needed to better understand the costs, benefits, opportunities and challenges of such programs. Compiled and written by the University of Wisconsin Extension and the Product Stewardship Institute, this report provides an in depth look at total current sales of household pharmaceuticals in Wisconsin and the rate at which those pharmaceuticals are wasted. The report then assesses current take-back programs, identifies barriers to higher collection rates, and explores potential alternatives for pharmaceutical destruction, program funding, collection and outreach.