The surging demand for electrical and electronic equipment (EEE) comes with the predicament of handling waste EEE (WEEE) or e-waste. The situation is even more complicated in South Asia due to the large-scale legal/illegal import of EEE and WEEE, which are handled primarily by the informal sector using rudimentary processes. Based on bibliometric analysis, we shortlisted about 200 articles to outline the country-wise status of e-waste in South Asian countries, challenges with informal e-waste recycling (IER) processes, and associated risk due to a cocktail of micro-pollutants. Precious metal recovery processing IER facilities are hotspots of hazardous substances including micro-pollutants such as toxic metals, plastic additives, polychlorinated biphenyls, perfluoroalkyl and polyfluoroalkyl substances, and brominated flame-retardants, commonly found in EEE. Additionally, dioxins/furans, polycyclic aromatic hydrocarbons, and micro- and nano plastics are released during IER processes. India, Bangladesh, and Pakistan are key contributors to e-waste generation, and urbanized economic centers have significant evidence of a cocktail of aforementioned micro-pollutants having a deleterious impact on the environment and public health. To promote sustainable e-waste management in South Asian countries, we recommend formalizing the e-waste recycling particularly for the metal recovery process, encouraging global partnerships, and incentivizing the extended producer responsibility rules in the region.