In this paper, the administration-driven WEEE management system in Europe and the market-driven end-of-life automobile management system in the US are studied first in this paper. Successful experiences and deficiencies of each system are investigated and compared. Then the potentials for integrating these two systems under each single-instrument-dominant scenario are identified followed by the discussion on key factors for soundly building an integrated system under various scenarios in general. Based on these achievements, the WEEE management system in China is taken as an example to demonstrate how to practically set up an integrated system in such a specific conditions, so that the application of EPR principle could be better promoted in a more economic efficient and ecological effective manner.